1. On April 27, 1825, the first permanent settlement in what is now Colorado was established by French Canadian trappers and traders at a site near present-day Fort Lupton.

2. April 27, 1914, saw the deadliest tornado in Colorado history strike downtown Sterling, killing 17 people and causing widespread destruction.

3. In 1961, on April 27, astronaut Scott Carpenter became the second American to orbit the Earth as part of the Mercury-Atlas 7 mission.

4. On April 27, 2002, the opening of the Colorado Mammoth's first ever playoff game drew a crowd of 18,743, setting a new attendance record for a National Lacrosse League game.

5. In 2019, on April 27, Denver hosted the first-ever Festivus Games, a functional fitness competition for novice and intermediate athletes.