1. South Carolina becomes a British colony (1712): On April 6, 1712, the Lords Proprietors of the Province of Carolina sold their entire ownership of the southern part of Carolina, including present-day South Carolina, to the British Crown. This made the area a British colony and changed the political and economic landscape of the region.

2. The Union blockade begins during the Civil War (1861): On April 6, 1861, the Union Navy established a blockade of Southern ports, including Charleston, South Carolina. This blockade was a key element in the Union's strategy to defeat the Confederacy during the Civil War and had a profound impact on the South Carolina economy.

3. Fort Sumter is bombarded (1863): On April 6, 1863, Confederate forces in Charleston Harbor opened fire on Union-held Fort Sumter, beginning a two-year siege of the fort. The battle had a significant impact on the Civil War and was a defining moment in South Carolina's history.

4. Clemson University is founded (1889): On April 6, 1889, Clemson University was founded in Clemson, South Carolina. The university has grown to become one of the largest and most prestigious colleges in the state, with a wide range of academic programs and a strong athletic program.

5. Toyota opens a manufacturing plant in South Carolina (2003): On April 6, 2003, Toyota opened a manufacturing plant in Georgetown, South Carolina, marking the company's first wholly owned plant in North America. The facility produces engines and transmissions for Toyota vehicles and has been a major source of economic growth and employment in the region.