1. On August 25, 1870, the Missouri Pacific Railroad was completed to Sedalia, Missouri. This allowed for greater transportation of goods and people across the state.

2. In 1929, on August 25th, the first Transcontinental Air Race began in New York City and ended in Los Angeles. The race stopped in St. Louis, Missouri, marking an early milestone in aviation history.

3. In 1831, on August 25th, John Sappington, a Missouri physician, successfully treated the first recorded case of malaria in the United States. He used quinine, a treatment derived from the bark of the South American cinchona tree, to cure the patient.

4. On August 25, 1977, Missouri Senator Stuart Symington died. Symington was a prominent political figure in Missouri and a key player in the formation of the United States Air Force.

5. On August 25, 1911, the Battleship Missouri was launched from Newport News, Virginia. The Missouri would go on to serve in both World War II and the Gulf War, and is best known as the site of the formal surrender of Japan in 1945. The ship is named for the state of Missouri.