In 1764, July 22 marked the date that George Read, one of Delaware's signatories of the Declaration of Independence, was born in Cecil County, Maryland. Read went on to become a prominent lawyer, politician, and delegate to the Continental Congress.

On July 22, 1862, Delaware voted to approve the Thirteenth Amendment to the United States Constitution, which abolished slavery and involuntary servitude.

July 22, 1916, saw the birth of famous blues singer and guitarist, Arthur "Big Boy" Crudup in Forest, Mississippi. Crudup later relocated to Delaware and worked at the DuPont Company while performing in local clubs and bars.

In 1973, July 22 marked the dedication of the Brandywine Battlefield Park in Chadds Ford, Pennsylvania. The park commemorates the Revolutionary War battle fought nearby on September 11, 1777, in which Delaware soldiers played a significant role.

July 22, 2013, saw the discovery of the remains of a prehistoric giant ground sloth in the White Clay Creek State Park in Newark, Delaware. The sloth, which lived around 100,000 years ago, weighed an estimated 1,500 pounds and stood up to 20 feet tall on its hind legs.