1. In 1812, the first Native American treaty was signed at Fort Wayne, Indiana. The treaty was between the United States government and several Native American tribes, including the Miami, Potawatomi, and Delaware, and it established boundaries for their lands.

2. In 1849, the first railroad in Indiana was completed from Madison to Indianapolis. This helped to connect the state with other parts of the country and facilitated the transportation of goods and people.

3. In 1873, Susan La Flesche Picotte, the first Native American woman to become a licensed physician in the United States, was born in the Omaha Indian Reservation in Nebraska. She later moved to Indiana and worked as a physician at the St. Francis Hospital in Lafayette.

4. In 1928, Amelia Earhart became the first woman to fly across the Atlantic Ocean as a passenger on a flight from Newfoundland to Wales. After her historic flight, she became a celebrity and made several stops in Indiana during her national tour.

5. In 1964, the Indiana University basketball team won their first NCAA Championship by defeating Duke University in the final. The team was led by coach Branch McCracken and star player Walt Bellamy, who went on to have a successful career in the NBA.