1. On March 22, 1630, the first settlement of the Massachusetts Bay Colony was established in what is now Charlestown. The colony played a crucial role in the growth and development of Massachusetts and New England as a whole.

2. In 1765, the British Parliament passed the Stamp Act, a controversial tax on printed materials that was deeply opposed by the colonists. This sparked a period of unrest and protest in Massachusetts, and helped set the stage for the American Revolution.

3. On March 22, 1873, Susan B. Anthony visited Massachusetts and gave a powerful speech on women's suffrage. Anthony was a leading advocate for women's rights and played a pivotal role in the movement to secure the right to vote for women.

4. In 1912, the Bread and Roses Strike began in Lawrence, Massachusetts. The strike was a major labor struggle that pitted textile workers against powerful factory owners, and ultimately helped to improve working conditions and win better wages for workers across the state.

5. On March 22, 2015, Boston Mayor Marty Walsh announced a new initiative to support small businesses in the city. The program, called "Main Streets," aims to help entrepreneurs and small business owners succeed and thrive in Massachusetts' vibrant economy.