1. On March 22, 1784, the South Carolina General Assembly established the College of Charleston. The college, originally known as the College of South Carolina, is now a public liberal arts and sciences university and is the oldest institution of higher education in the state.

2. On March 22, 1822, Denmark Vesey was arrested for planning what would have been one of the largest slave uprisings in American history. Vesey, a former slave himself, had organized a group of enslaved people in Charleston to take up arms against their masters and seize control of the city. Vesey and 34 others were ultimately executed for their involvement in the planned rebellion.

3. On March 22, 1865, Confederate forces under the command of General Wade Hampton III engaged in the Battle of Bentonville in North Carolina. The battle, which was part of the final stages of the Civil War, saw the Confederates suffer a major defeat at the hands of Union forces. Many South Carolinians were involved in the fighting, as the state had supplied a significant portion of the Confederate troops.

4. On March 22, 1961, civil rights activists led by the Reverend Jesse Jackson conducted a sit-in at a segregated lunch counter in Rock Hill, South Carolina. The group was arrested and charged with breach of peace, but their bold actions helped to galvanize the civil rights movement in the state and across the country.

5. On March 22, 1991, Hurricane Hugo made landfall in South Carolina, causing widespread damage and destruction. The storm, which was one of the strongest and most destructive hurricanes to ever hit the United States, devastated large areas of the state and caused billions of dollars in damage. However, the state rallied in the aftermath of the disaster, with communities coming together to rebuild and recover.