1. On March 27, 1836, the Treaty of Doak's Stand was signed between the United States and the Choctaw Nation, which resulted in the removal of thousands of Choctaw people from their ancestral lands in Mississippi to Indian Territory in present-day Oklahoma.

2. On March 27, 1901, the Mississippi Legislature passed a bill to establish the Mississippi Industrial Institute and College, which would later become Mississippi University for Women. The institution was the first state-supported college for women in the United States.

3. On March 27, 1943, the U.S. Army Air Forces established the Tupelo Army Air Field in Lee County, Mississippi, as a training base for pilots during World War II. The base later became the Tupelo Regional Airport.

4. On March 27, 1964, civil rights activist Fannie Lou Hamer gave a speech at the Democratic National Convention in Atlantic City, New Jersey, where she spoke about the brutality she had experienced while fighting for voting rights in Mississippi.

5. On March 27, 2018, Mississippi Governor Phil Bryant signed into law a bill banning abortion after 15 weeks, making it the most restrictive abortion law in the country at the time. The law was later blocked by a federal judge.