1. On March 6, 1820, the Missouri Compromise was passed, allowing Missouri to enter the Union as a slave state and Maine as a free state, maintaining the balance between free and slave states in the United States at the time.

2. On March 6, 1865, Confederate General Sterling Price's army was defeated by Union troops at the Battle of Waynesville. This was one of the last battles of the Civil War in Missouri.

3. In 1930, the Missouri State Highway Patrol was established on March 6, making it one of the oldest state law enforcement agencies in the United States.

4. On March 6, 1941, President Franklin D. Roosevelt gave a speech in St. Louis, Missouri, calling for increased support for the Allied powers ahead of the United States' entry into World War II.

5. In 2017, the National Blues Museum opened in St. Louis on March 6. The museum celebrates the history of blues music in America and its impact on popular culture.