1. In 1823, the Treaty of St. Joseph was signed between the United States and the Miami tribe. The treaty ceded a large portion of Miami land in present-day Indiana to the U.S. government.

2. On May 16, 1857, the first Indianapolis 500 was held at the Indianapolis Motor Speedway. The race has become a legendary event in American motorsports and continues to draw huge crowds.

3. In 1905, the tornado outbreak of May 1905 struck parts of Indiana, causing significant damage and claiming 238 lives. It remains one of the deadliest tornado outbreaks in U.S. history.

4. On May 16, 1925, the famous Scopes Trial began in Dayton, Tennessee. Although the trial took place in Tennessee, many Hoosiers followed the case closely as it was a pivotal moment in the debate over teaching evolution in schools.

5. In 1969, the Indiana University basketball team won the NCAA championship by defeating the Purdue Boilermakers. The Hoosiers' victory was significant not only for their first national title in basketball, but also for their role in breaking down racial barriers in college sports.