1. On May 21, 1935, the West Virginia State Capitol Building was officially dedicated. The governor at the time, William G. Conley, gave a speech at the ceremony, which was attended by over 15,000 people.

2. The town of Moundsville, West Virginia, was founded on May 21, 1830. Originally named Elizabethtown, the town was renamed in honor of nearby Native American burial mounds.

3. On May 21, 1861, Virginia seceded from the Union and joined the Confederacy. However, not all parts of Virginia agreed with this decision, and a group of delegates from western Virginia gathered in Wheeling to form the Restored Government of Virginia.

4. The first graduating class of West Virginia University's School of Medicine received their degrees on May 21, 1907. The school was established in 1902 and has since become a leading medical institution.

5. On May 21, 1914, the West Virginia Coal Mine Workers' Strike began. The strike involved over 15,000 coal miners across the state and lasted for nearly two months. The strikers were demanding better pay, shorter work hours, and improved working conditions.