1. In 1861, the first Colorado state constitution was drafted on May 22nd in Denver. This marked a significant moment in Colorado history as it paved the way for Colorado to become a state.

2. On May 22, 1934, Clyde Cessna completed the first flight of the Cessna CR-3, which was a racing plane built for the National Air Races. This was a major milestone for the aviation industry as it helped establish Cessna as a leading aircraft manufacturer.

3. In 1970, a major earthquake struck the town of Trinidad, Colorado on May 22nd. The earthquake was measured at a 6.1 magnitude and caused significant damage to buildings and infrastructure. However, no fatalities or major injuries were reported, thanks in part to the early warning systems that were in place.

4. On May 22, 2008, Colorado became the first state in the US to legalize medical marijuana through a ballot initiative. This was a groundbreaking moment for the state and helped pave the way for other states to follow suit in legalizing marijuana for medical purposes.

5. In 2010, the Fourmile Canyon Fire started on May 22nd near Boulder, Colorado. The fire burned over 6,000 acres and destroyed over 160 homes, marking it as one of the most destructive wildfires in Colorado history. The fire was eventually contained after several weeks, but it serves as a reminder of the devastating impact that wildfires can have on communities and the environment.