1. On May 6, 1812, a group of Native Americans led by Tecumseh and his brother Tenskwatawa, often referred to as The Prophet, attacked a small group of soldiers led by U.S. Army Captain Abraham Williams at the mouth of the Auglaize River near modern-day Fort Jennings. This event, known as the Attack on Fort Jennings, was one of the first engagements of the War of 1812 in the Ohio region.

2. On May 6, 1882, the Ohio State Penitentiary in Columbus opened its doors to its first prisoners. It was considered a state-of-the-art facility at the time, but would later become notorious for its overcrowding and inhumane conditions. The prison was closed in 1984 and demolished in 1998.

3. May 6, 1935 saw the dedication of the Ohio River Bridge in Cincinnati, connecting the Queen City to neighboring Kentucky. The bridge was designed by famed architect Paul Philippe Cret and became a symbol of unity between the two states.

4. The Ohio Primary Election was held on May 6, 2008, with both the Democratic and Republican presidential nominations still up for grabs. Ohio played a pivotal role in the election, with voters helping to seal the nomination for Barack Obama on the Democratic side and John McCain on the Republican side.

5. May 6, 2015 marked the end of the search for Amanda Berry, Gina DeJesus, and Michelle Knight, who had been kidnapped and held captive in a Cleveland home for over a decade. Berry managed to escape and call for help, leading to the rescue of all three women and the eventual capture and imprisonment of their kidnapper, Ariel Castro. The case received national attention and brought renewed focus to the issue of missing persons.