1. In 1792, the Ohio Company, which had been established to colonize the Northwest Territory, held its first meeting in Boston. The company had a significant impact on the development of Ohio and the entire region.

2. In 1886, a major tornado struck the town of Mount Vernon, Ohio. The tornado caused significant damage and resulted in several deaths, underscoring the importance of preparation for natural disasters.

3. In 1914, Ohio Governor James Cox signed into law the Smith-Lever Act, which established a national system of cooperative extension services to provide education and support to farmers and rural communities. This act had a transformative impact on agriculture in Ohio and throughout the country.

4. In 1945, Ohioan Arthur Vandenberg, a senator from Grand Rapids, Michigan, delivered a famous speech in the Senate calling for bipartisan cooperation in foreign policy. The Vandenberg Resolution, as it became known, significantly altered the course of American foreign policy in the aftermath of World War II.

5. In 1974, Ohioan Thomas C. Duffy became the first astronaut from the state to fly in space. Duffy was a member of the crew of the Skylab 3 mission, which orbited the Earth for 59 days and conducted numerous scientific experiments.