1. Louisiana State University's First Football Game
On November 21, 1893, Louisiana State University played its first football game ever. The game was played against Tulane University and ended in a 34-0 victory for Tulane.

2. Louisiana Purchase Treaty
On November 21, 1803, the Louisiana Purchase Treaty was ratified by the US Senate, officially making Louisiana a part of the United States. This purchase doubled the size of the country and helped strengthen American control over the Mississippi River and its trade routes.

3. St. Tammany Parish Established
St. Tammany Parish was established on November 21, 1810, making it the fifth parish in Louisiana. It is named after a Choctaw chief known for his friendship with early settlers of the area.

4. Cottonport Founded
Cottonport, a town in Avoyelles Parish, was founded on November 21, 1888. The town was named for its location at the heart of Louisiana's cotton-growing region.

5. Baton Rouge Bus Boycott
On November 21, 1953, Baton Rouge residents staged a bus boycott to protest discriminatory seating practices. The boycott's success led to the integration of Baton Rouge busses and served as a precursor to the Montgomery bus boycotts of the 1960s.