1. On November 21, 1980, the MGM Grand Hotel and Casino in Las Vegas was devastated by a fire that killed 85 people and injured 650 more. Dubbed one of the deadliest hotel fires in American history, the incident resulted in major changes to building codes and fire safety regulations in Nevada and across the country.

2. The date also marks the anniversary of the founding of Nevada's oldest continuously operating newspaper, The Daily Appeal, which began publication in Carson City on November 21, 1865. Over the years, the paper has covered everything from local politics to national news, and remains a vital source of information for residents of the state capital and surrounding area.

3. November 21 is also significant in the history of the University of Nevada, Reno, which was first established on that date in 1874. Originally known as the State University of Nevada, the institution has grown into a major research university with a diverse student body and a wide range of academic programs.

4. In 2011, on November 21, the Las Vegas City Council approved a measure to build a new sports arena on the site of the city's former convention center. The facility, which was later named the T-Mobile Arena, has since become a popular venue for major concerts, sporting events, and other entertainment.

5. Finally, November 21 is also significant for its association with the legendary Wild West showman Buffalo Bill Cody, who passed away on that date in 1917. Cody was a frequent visitor to Nevada and performed his famous "Buffalo Bill's Wild West" show in Reno and other cities across the state. Today, he is remembered as a larger-than-life figure who helped shape the popular image of the American West.