1. Ohio State University was founded on October 16, 1870: The university, located in Columbus, Ohio, is counted among the most comprehensive and diversified public universities in the United States.

2. The Ohio Statehouse cornerstone was laid on October 16, 1839: The Statehouse is located in Columbus and is the seat of the government of the U.S. state of Ohio.

3. The Great Dayton Flood occurred on October 16, 1908: The flood was caused by heavy rainfall and flooding of the Great Miami River. The flood caused significant damage to property and claimed over 300 lives.

4. The Treaty of Greenville was signed on October 16, 1795: The treaty was signed between the United States government and several Native American tribes, including the Shawnee, Delaware, and Wyandot. The treaty ended the Northwest Indian War and opened up the Northwest Territory to settlement.

5. The first commercial airline flight was operated on October 16, 1926: The flight was operated by Western Air Express, which later became Western Airlines. The flight was from Salt Lake City, Utah to Los Angeles, California with a stop in Las Vegas, Nevada.