1. On October 21, 1805, the New York State Legislature approved a charter for Columbia College, which later became Columbia University, making it the first institution of higher education in New York.

2. The first subway line in New York City, the Interborough Rapid Transit Company (IRT) subway, opened on October 21, 1904. The line ran from City Hall to 145th Street in Harlem and was an instant success, carrying over 150,000 passengers on its first day.

3. On October 21, 1929, the New York Stock Exchange experienced one of its worst days in history, known as “Black Monday.” The crash marked the beginning of the Great Depression, which would have a profound effect on the city and the country.

4. The famous movie “Breakfast at Tiffany’s” premiered on October 21, 1961, at the Music Hall Theater in New York City. The film, starring Audrey Hepburn and based on the novella by Truman Capote, has become a classic and is recognized as one of the greatest American films of all time.

5. On October 21, 2007, the New York Giants faced off against the Miami Dolphins in the first regular-season NFL game played in London, England. The Giants won 13-10, making them the first team to win a regular-season game outside of North America.