1. In 1844, the Baltimore and Ohio Railroad was completed, connecting Baltimore with the Ohio River and establishing Maryland as an important transportation hub. This led to increased trade and economic growth in the state.

2. On October 22, 1861, Union General George B. McClellan established his headquarters at the historic Clara Barton house in Glen Echo, Maryland. Barton was a noted Civil War nurse and founder of the American Red Cross.

3. The first professional football game in Baltimore was played on October 22, 1950, between the Baltimore Colts and the New York Yanks. The Colts won 55-13, marking the beginning of a long-lasting love affair between the city and the sport.

4. The Chesapeake Bay Bridge-Tunnel, connecting Maryland's Eastern Shore with Virginia's Eastern Shore, opened on October 22, 1964. At the time, it was the longest bridge-tunnel complex in the world and a major engineering feat.

5. On October 22, 2002, John Allen Muhammad and Lee Boyd Malvo were arrested in Maryland for their 10-month shooting spree that killed 10 and injured three in the D.C. area. The arrests brought an end to the nationwide manhunt for the "Beltway Snipers."