1) On October 22, 1833, Mississippi's first railroad was chartered. The plan was to construct a line from Natchez to Clinton, but it was eventually abandoned due to financial difficulties.

2) On October 22, 1862, Confederate forces under General Earl Van Dorn launched an attack on Union troops at Corinth during the Civil War. The battle ended in a Union victory, but not before causing significant casualties on both sides.

3) In 1946, a tornado struck Tupelo on October 22, killing 233 people and injuring more than 1,000. The disaster is still one of the deadliest tornadoes in U.S. history.

4) On October 22, 1962, U.S. President John F. Kennedy gave a speech at the University of Mississippi in Oxford, where he emphasized the need for racial integration and civil rights in the state.

5) In 1998, Mississippi State University became the first college in the state to offer a degree in veterinary medicine on October 22. The program has since expanded and is now one of the top veterinary schools in the country.