1. On October 22, 1811, the first steamboat to navigate the Mississippi River, the New Orleans, arrived in Nashville, Tennessee.

2. In 1930, Memphis, Tennessee became the first city in the United States to have a public school system that provided free transportation for both black and white students.

3. On October 22, 1844, the first telegraph lines in Tennessee were established between Nashville and Louisville, Kentucky.

4. The Battle of Parker's Cross Roads, also known as the Battle of Parkersburg, took place on October 22, 1862, during the American Civil War. The Union Army was able to force the Confederate Army to retreat, which helped secure the state for the Union.

5. On October 22, 1962, President John F. Kennedy addressed thousands of students at the University of Tennessee in Knoxville. This speech is famous for his remarks on diversity and inclusion, stating, "If we cannot end now our differences, at least we can help make the world safe for diversity."