1. In 1820, the Treaty of Traverse des Sioux was signed on October 4, between the United States government and Dakota Native American tribes. The treaty ceded over 24 million acres of land to the U.S. and allowed for the creation of a reservation for the Dakota people.

2. On October 4, 1887, the University of Minnesota hosted its first football game against Hamline University. The Golden Gophers won 14-3, marking the beginning of the university's football tradition.

3. The first World Series game was played on October 4, 1903, between the Boston Americans and the Pittsburgh Pirates. Although the game did not take place in Minnesota, it is noteworthy as Minnesota Twins (formerly the Washington Senators) have played in three World Series.

4. The Mayo Clinic was founded in Rochester, Minnesota on October 4, 1915, by Dr. William Worrall Mayo and his two sons. The clinic has since become one of the most well-respected medical institutions in the world, known for its innovative approach to healthcare.

5. On October 4, 1991, the Minnesota Twins won their second World Series championship by defeating the Atlanta Braves in a dramatic Game 7. The Twins' victory sparked celebrations across Minnesota and cemented the team as one of the most beloved sports franchises in the state's history.