1. Battle of Point Pleasant: On September 19, 1774, the Battle of Point Pleasant occurred in what is now Point Pleasant, West Virginia. It was the only major battle of Lord Dunmore's War. The battle was fought between Virginia militia, led by Colonel Andrew Lewis, and a coalition of Native American tribes, led by Shawnee Chief Cornstalk. The Virginia militia won the battle, which led to the withdrawal of Native Americans from the Ohio Valley during the American Revolutionary War.

2. Golden Delicious Apple: September 19 is celebrated as National Golden Delicious Apple Day in the United States. The Golden Delicious apple was developed in Clay County, West Virginia, in 1912 by horticulturist Anderson "Mike" Mullins. The apple was named "Golden Delicious" in 1916 and has since become one of the most popular apple varieties in the world.

3. John Knowles Fitch: On September 19, 1822, John Knowles Fitch was born in Wheeling, West Virginia. He was a prominent lawyer and politician who served as the 5th Governor of the State of Indiana from 1856 to 1860. He also served as a U.S. Congressman from Indiana from 1863 to 1867.

4. New River Gorge National River: On September 19, 1978, the New River Gorge National River was established in West Virginia. The National River is managed by the National Park Service and covers a 53-mile stretch of the New River. The area is known for its rugged beauty, whitewater rapids, and outdoor recreational opportunities.

5. Michael Smith: On September 19, 1951, Nobel Prize-winning biochemist Michael Smith was born in Blackpool, England. Smith was a professor at the University of British Columbia and developed the first site-directed mutagenesis technique, which allowed scientists to change specific amino acids in a protein. Smith received the Nobel Prize in Chemistry in 1993 for his work on the technique. He lived in Morgantown, West Virginia, for several years while working at West Virginia University.