1. On September 21, 1927, a devastating flood swept through Mississippi, leaving over 200,000 people homeless and causing extensive damage to property and infrastructure. This disaster, which was caused by heavy rainfall and inadequate levee systems, highlighted the need for improved flood control measures in the region.

2. On September 21, 1934, famed blues musician B.B. King was born in Itta Bena, Mississippi. King went on to become one of the most influential guitarists in American music history, earning numerous accolades for his distinctive style and virtuosic playing.

3. In 1962, James Meredith became the first African American student to enroll at the University of Mississippi, achieving a major milestone in the struggle for civil rights. Meredith's enrollment was met with significant opposition from white supremacist groups, leading to violent clashes and the deployment of federal troops to maintain order.

4. On September 21, 1981, baseball legend Pete Rose recorded his 4,192nd hit, breaking Ty Cobb's record for the most career hits in Major League Baseball. Rose, who spent much of his career playing for the Cincinnati Reds, remains one of the most beloved and controversial figures in the sport's history.

5. In 2013, the Mississippi Civil Rights Museum was established in Jackson, commemorating the struggles and achievements of the state's African American community in their fight for equal rights and justice. The museum features exhibits on the state's civil rights activists, leaders, and events, and serves as an important symbol of progress and hope for future generations.