1. On September 21, 1892, the first issue of the Grand Forks Daily Herald was published in North Dakota. The newspaper became a major source of news and information for the region and remains in circulation to this day.

2. In 1926, on September 21, the new North Dakota State Capitol building was dedicated in Bismarck. The neoclassical structure, designed by architect Joseph Bell DeRemer, is a prominent landmark in the state and houses the offices of the governor and other state officials.

3. The Lewis and Clark Expedition, which explored the American West in the early 1800s, camped near the present-day city of Washburn, North Dakota, on September 21, 1804. The expedition recorded detailed accounts of the native flora and fauna, as well as the interactions with American Indian tribes.

4. On September 21, 1957, the University of North Dakota Fighting Sioux football team defeated the West Texas State Buffaloes in a record-breaking game. The final score was 103-0, with the Fighting Sioux setting a new record for the most points scored in a college football game.

5. In 1971, the North Dakota State Fairgrounds in Minot suffered extensive flood damage after the Souris River overflowed its banks. The flood occurred on September 21, and forced the fair to be canceled for the first time in its history. The fairgrounds were rebuilt and the event continued to thrive in subsequent years.