1. On September 22, 1821, the state of Missouri was admitted to the Union as the 24th state. Missouri was the first state to be carved out of the Louisiana Territory and its admission helped to maintain the balance of free and slave states in the United States.

2. On September 22, 1864, the Battle of Jefferson City occurred during the American Civil War. Confederates under the command of General Sterling Price attacked the Missouri state capital, but were repulsed by Union forces under General David Todd.

3. In 1906, on September 22, the first fully operational airplane in Missouri took flight. Piloted by Charles K. Hamilton, the flight took place at the Missouri State Fair in Sedalia and lasted for six minutes.

4. On September 22, 1931, the Missouri State Penitentiary in Jefferson City was destroyed by fire. The blaze caused the death of 57 inmates and led to a demand for prison reform in the state.

5. In 1961, on September 22, the Central Missouri State College (now known as University of Central Missouri) hosted a speech by President John F. Kennedy. The President spoke on the importance of education and the need for advancements in science and technology to propel the nation forward.