1. In 1862, a devastating fire broke out in Virginia City, destroying many of its buildings and leaving dozens of people homeless. The fire was started by a careless baker, who left his oven unattended while he went to get some more wood.

2. On September 22, 1975, the first episode of the television series "Vega$" aired. The show, which starred Robert Urich as a private investigator in Las Vegas, ran for three seasons and was known for its glamorous setting and action-packed storylines.

3. In 1994, the MGM Grand Hotel in Las Vegas was the site of a tragic fire that killed 85 people and injured hundreds more. The fire was caused by an electrical problem in one of the hotel's restaurants and spread quickly, trapping many guests in their rooms.

4. On September 22, 2006, the Palms Casino Resort in Las Vegas opened the Playboy Club, a high-end nightclub and casino that was modeled after the famous Playboy Mansion. The club featured a Playboy Bunny dealer and a variety of upscale amenities, but closed in 2012 due to declining revenues.

5. In 2017, the Las Vegas Strip was the site of one of the deadliest mass shootings in U.S. history. On September 22 of that year, a gunman opened fire on a crowd of concertgoers from his room in the Mandalay Bay Hotel and Casino, killing 58 people and injuring more than 800 others. The tragedy shocked the nation and prompted renewed calls for stricter gun control laws.