1. Virginia became a state: On September 22, 1788, Virginia officially became the 10th state to be admitted into the Union. Virginia played a significant role in the American Revolution and the drafting of the United States Constitution, and this milestone marked the state's transition from colony to statehood.

2. The Battle of Fisher's Hill: During the Civil War, on September 22, 1864, the Union army led by General Philip Sheridan engaged the Confederate army under General Jubal Early at the Battle of Fisher's Hill. The Union won the battle, and it marked the beginning of the end for Confederate resistance in the Shenandoah Valley.

3. The Virginia Theatre bombing: On September 22, 1984, a bomb detonated inside the Virginia Theatre in Waynesboro, Virginia. The incident was a targeted attack aimed at a Jewish businessman who owned the building. Although nobody was hurt in the bombing, the incident sparked outrage and led to increased scrutiny on hate crimes and extremism in the United States.

4. Virginia Tech Shooting: On September 22, 2006, a gunman opened fire at Virginia Tech University, killing 32 people and injuring 17 more. It was the deadliest mass shooting in modern American history at the time. The incident brought worldwide attention to the issue of gun violence and led to increased efforts to improve campus safety and mental health resources for students.

5. NASA Langley Research Center: On September 22, 1917, the National Advisory Committee for Aeronautics (NACA) established the Langley Memorial Aeronautical Laboratory in Hampton, Virginia. Today, it is known as the NASA Langley Research Center and has played a significant role in advancing aeronautics and space exploration. The center was instrumental in developing technology used in the first manned moon landing in 1969.