1. In 1862, a deadly tornado outbreak struck parts of Wisconsin on September 22, killing at least 12 people and causing widespread destruction. Some of the hardest-hit areas included Ozaukee, Sheboygan, and Washington counties.

2. On September 22, 1950, the Green Bay Packers played their first home game at newly-built City Stadium (later renamed Lambeau Field). The Packers defeated their rivals, the Chicago Bears, by a score of 41-10.

3. In 1862, General William S. Rosecrans and his Union army won a decisive victory over Confederate forces at the Battle of Iuka, Mississippi. This victory was significant for Wisconsin soldiers, who made up a sizable portion of Rosecrans' army.

4. On September 22, 1835, the first issue of the Milwaukee Sentinel newspaper was published. The Sentinel quickly became one of Wisconsin's most influential papers, covering everything from politics to business to entertainment.

5. In 1940, famed Wisconsin conservationist Aldo Leopold wrote a letter to his friend and fellow conservationist, Olaus Murie, describing a challenging hunting trip in Wyoming. The letter, known as the "Thinking Like a Mountain" essay, would later become a cornerstone of modern environmentalism.