1. On September 22, 1887, the first cattle roundup in the state of Wyoming was held in Johnson County. The roundup helped to organize and manage the large herds of cattle that were being raised in the region, and it helped to establish Wyoming as a major center for agriculture and ranching.

2. On September 22, 1913, the University of Wyoming opened its doors for the first time. The school had been established by an act of the state legislature two years earlier, and it quickly became a vital center for higher education in the region.

3. On September 22, 1937, the first ever female mayor in the state of Wyoming was elected. Ada C. Miller, a schoolteacher and community leader, was elected as the mayor of Midwest, a small town in the center of the state.

4. On September 22, 1950, the United States Air Force began operating the first-ever intercontinental ballistic missile (ICBM) test program in the state of Wyoming. The program, which was known as Project MX-1593, launched missiles from a site near the town of Rawlins, and it was a significant milestone in the development of United States missile technology.

5. On September 22, 1976, the world-famous Old Faithful Inn in Yellowstone National Park was designated as a National Historic Landmark. The Inn had opened in 1904, and it remains one of the most iconic and popular attractions in the park today.