1. On September 27, 1904, the first game of football was played at the University of Wyoming. The game was against the Laramie High School and the University team won 40-0.

2. In 1939, on September 27, the first Catholic parish in Natrona County was established in Casper, Wyoming. The first mass was held in a small chapel on North Center Street.

3. On September 27, 1943, the Wyoming Women's Relief Corps was formally organized in Cheyenne, Wyoming. The organization provided support and assistance to veterans and their families.

4. In 1959, on September 27, the first major oil discovery in the Powder River Basin was made in Wyoming. This discovery led to the development of the basin and contributed significantly to the state's economy.

5. On September 27, 1996, the town of Jackson, Wyoming was evacuated due to a wildfire that burned over 30,000 acres. The fire was the largest wildfire in the state's history at the time and caused significant damage to the area.