1. In 1757, the first meeting of the Pennsylvania Assembly was held in Philadelphia. The Assembly was created following the establishment of Pennsylvania as a colony in 1681, and was responsible for making laws and governing the colony.

2. On September 6, 1796, celebrated American painter Charles Willson Peale opened his Philadelphia Museum, which showcased a wide variety of natural history and scientific exhibits, as well as extensive collections of art and cultural artifacts. The museum was a popular destination for both locals and tourists, and was considered one of the most important cultural institutions in America at the time.

3. In 1837, the Delaware and Hudson Canal Company completed construction of the Honesdale Canal Basin in Honesdale, PA. The basin was a pivotal component of the Delaware and Hudson Canal, which provided a vital transportation link between the coal mines of northeastern Pennsylvania and the industrial centers of the eastern seaboard.

4. In 1868, the University of Pittsburgh was founded as the Pittsburgh Academy, with just three faculty members and 38 students. Over the years, the school underwent numerous name changes and expansions, becoming a major research institution and the largest university in the Pittsburgh metropolitan area.

5. September 6, 1901, marked the start of the Great Anthracite Coal Strike, which lasted for five months and involved over 100,000 coal miners across Pennsylvania. The strike was sparked by a dispute over wages and working conditions, and led to widespread protests, violence, and unrest. Ultimately, the coal companies agreed to several concessions, and the strike ended in a partial victory for the workers.