1. On March 21, 1622, the Powhatan Indian tribe launched a surprise attack on English settlements in Virginia, leading to the deaths of approximately 350 colonists. This event, known as the "Indian Massacre of 1622," upended relations between the English colonists and the Powhatans, leading to increased tension and conflict.

2. March 21, 1751 marked the founding of Wakefield Academy in Virginia. This school, located in the town of Wakefield, aimed to educate young men in the classics as well as practical subjects like mathematics and surveying. Wakefield Academy operated for over a century before eventually closing in 1863.

3. In 1865, the Confederate States of America held a council of war in Amelia Court House, Virginia on March 21. Attendees included President Jefferson Davis and his top military advisors, who discussed the dire state of the Confederacy and debated whether to continue the fight or surrender. Ultimately, the decision was made to retreat and regroup further south.

4. On March 21, 1951, the Virginia General Assembly approved the creation of the College of William and Mary's School of Law. This move marked the first time a public law school had been established in Virginia, and the School of Law continues to operate as part of the College of William and Mary.

5. In 1960, a civil rights demonstration was held in Richmond, Virginia on March 21. Led by the Student Nonviolent Coordinating Committee (SNCC), the demonstration aimed to protest segregation and discrimination in the city. Demonstrators were met with heavy resistance from police and segregationist groups, leading to violent clashes and numerous arrests. The event helped to galvanize the civil rights movement in Virginia and across the country.