1. In 1838, nearly 2,000 members of the Cherokee Nation were forcibly removed from their homes in Missouri and made to walk to Indian Territory (present-day Oklahoma) in what is now known as the Trail of Tears.

2. In 1915, the Federal Reserve Bank of St. Louis opened, becoming one of the 12 regional banks established to help stabilize the nation's banking system.

3. In 1978, the Royals baseball team won their first American League pennant, defeating the New York Yankees in the championship series and advancing to the World Series, where they lost to the Los Angeles Dodgers.

4. In 2000, Missouri's first presidential debate was held at Washington University in St. Louis, featuring candidates George W. Bush and Al Gore.

5. In 2013, a tornado outbreak struck the state, causing significant damage and resulting in three deaths. The town of Smithville was particularly hard hit, with over 200 homes destroyed or damaged.