1. In 1805, the Treaty of Fort Industry was signed between the United States government and several Native American tribes. The treaty ceded the land comprising modern-day northwest Ohio to the United States, opening the region for settlement.

2. The Ohio State Penitentiary opened its doors on October 21, 1834, becoming the first prison in Ohio. The penitentiary was known for its harsh conditions and brutal punishments, and it was eventually closed in 1984.

3. Ohio's first public library, the Cleveland Public Library, was founded on October 21, 1869. The library remains one of the largest and most respected public library systems in the country.

4. In 1913, a devastating flood struck the city of Dayton, Ohio, killing over 400 people and causing millions of dollars in damage. The flood remains one of the worst natural disasters in Ohio's history.

5. October 21, 1971, marked the dedication of the Rock and Roll Hall of Fame in Cleveland, Ohio. The museum honors the achievements of the greatest artists, producers, and others from the world of rock music. The Rock and Roll Hall of Fame is one of Ohio's most popular tourist attractions, drawing visitors from around the world.