1. On October 22, 1915, Ohio State defeated Northwestern in a historic football game held in Columbus. The final score was 23-0, and this game marked the first time that Ohio Stadium was used.

2. In 1962, astronaut John Glenn became the first American to orbit the Earth on October 22nd. Glenn was born in Cambridge, Ohio and was one of the original seven Mercury astronauts.

3. The Ohio State Reformatory, a former prison located in Mansfield, Ohio, opened on October 22, 1896. The prison is known for its unique and imposing Gothic architecture and has been featured in several movies, including The Shawshank Redemption.

4. On October 22, 1804, the Lewis and Clark Expedition reached the Ohio River after traveling hundreds of miles from their starting point in St. Louis. The expedition explored the territory that would become the western United States.

5. The first Oktoberfest held in Cleveland, Ohio took place on October 22, 1965. The festival is a celebration of German culture and features traditional food, beer, and music. It has become an annual tradition in Cleveland and draws thousands of visitors each year.