1. On September 28, 1821, the Ohio and Erie Canal's construction began. It was one of Ohio's most significant infrastructure projects, connecting Lake Erie in Cleveland to the Ohio River in Portsmouth, effectively linking the Great Lakes to the Mississippi River system.

2. In 1918, the deadliest train wreck in Ohio's history occurred on September 28 in Richmond. A passenger train crashed into a stopped freight train, killing 16 and injuring many more.

3. In 1982, the first Black bear hunt in Ohio's modern history occurred on September 28. The hunt, which was controversial, aimed to reduce the bear population in the southeastern part of the state.

4. On September 28, 1991, the Cincinnati Reds clinched the National League West title with a 5-3 win over the San Diego Padres. It was the team's first division title in seven years and the beginning of their run to a World Series championship.

5. In 2018, Ohio's second-tallest building, the Key Tower in Cleveland, was sold on September 28 for $267.5 million. The 57-story skyscraper stands at 947 feet tall and is the 23rd tallest building in the United States.