1. In 1829, the Ohio and Erie Canal was officially opened, connecting Lake Erie to the Ohio River. The canal made transportation easier and more efficient, leading to the growth and development of several cities along its route.

2. On October 5, 1944, the Cleveland Indians won their first World Series championship, defeating the St. Louis Cardinals in game six. The Indians had previously lost in the World Series in 1920 and 1948.

3. In 1970, the Kent State shootings occurred, where Ohio National Guard troops fired on unarmed students protesting against the Vietnam War. Four students were killed and nine were injured in the attack, sparking widespread protests and calls for an end to the war.

4. Ohioan Neil Armstrong, the first person to walk on the moon, was born on October 5, 1930, in Wapakoneta. Armstrong served as a naval aviator and test pilot before joining NASA and making history with the Apollo 11 mission in 1969.

5. On October 5, 1999, Michael Lower became the first person in Ohio to receive a heart-liver transplant. The transplant was performed at the Cleveland Clinic and helped to save Lower's life, allowing him to live for several more years with a new heart and liver.